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Additional examples of reported antagonists include irampanel (CAS RN 206260-33-5) and E-2007. Additional examples of reported antagonists include irampanel (CAS RN 206260- 33-5) and E-2007. Muscarinic Agents [0145] In certain embodiments, one or more muscarinic agents, preferably agonists, are useful in combination with a first neurogenic agent of the present invention. Non-limiting examples of muscarinic agents as known to the skilled person and useful herein include the following, . Structures, biological activity data, methods for obtaining biological activity data, methods of synthesis, modes of administration and pharmaceutical formulations for milameline and related compounds are disclosed in U.